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SUBSTITUTED BITHIAZOLES FOR THE TREATMENT OF CANCER

The present invention relates to novel chemotherapeutics, substituted bithazoles, with a potentially safer therapeutic profile. Discovered compounds inhibit human DNA topoisomerase II via an alternative mechanism, thus avoiding the DNA damage. This lowers the chances of cardiotoxicity and induction of secondary malignancies, side effects associated with clinically used topo II drugs. Compounds can be used as a standalone chemotherapy or in combination with other anticancer drugs.

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ONE-STEP SYNTHESIS OF GLYCIDOL FROM GLYCEROL IN GAS-PHASE FIXED-BED CONTINOUS FLOW REACTOR OVER ALKALI METAL PROMOTED ALUMINOSILICATE ZEOLITE CATALYST

The present invention relates to the use of alkali metal promoted aluminosilicate zeolite catalyst for the direct gas-phase conversion of glycerol to glycidol, as well as to a process for the production of glycidol from glycerol in a fixed-bed continuous flow reactor in the presence of such a heterogeneous catalyst. The method comprises conversion of glycerol to glycidol in the range of temperature 250-450 °C, glycerol concentration 1-60 wt%, total gas hourly space velocity 100-2500 h-1, weight of catalyst 0.5-5.0…

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SUSTAINABLE PRODUCTION OF ALLYL ALCOHOL: GAS-PHASE CONVERSION OF GLYCEROL OVER METALS PROMOTED ALUMINOSILICATE ZEOLITE CATALYSTS IN A FIXED-BED CONTINUOUS FLOW REACTOR

The present invention relates to the use of a tri-metallic promoted aluminosilicate zeolite catalyst for the direct gas-phase conversion of glycerol to allyl alcohol, as well as to a process for the production of allyl alcohol from glycerol in a fixed-bed continuous flow reactor in the presence of such heterogeneous catalysts. The method comprises conversion of glycerol to allyl alcohol in the range of temperature 250-450 °C, glycerol concentration 1-60 wt%, total gas hourly space velocity 100-2000 h-1, the weight…

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SUSTAINABLE PROCESS FOR PRODUCING MUCONIC, HEXENEDIOIC AND ADIPIC ACID (AND THEIR ESTERS) FROM ALDARIC ACIDS BY HETEROGENEOUS CATALYSIS

The Institute’s invention is a process based on selective dehydroxylation of aldaric acids derived from C6 oxidized sugars. The selective dehydroxylation is carried out in the presence of a heterogeneous carbon supported rhenium catalyst (Re/C) and a short chain primary or secondary alcohol (MeOH, EtOH, 2-PrOH,…). Under an inert (N2) atmosphere, unsaturated dimethyl ester of a C6 dicarboxylic acid is formed. If H2 is present in the gas phase, it is dissolved in MeOH and adsorbed on the catalyst surface,…

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Naložbo sofinancirata Republika Slovenija in Evropska unija iz Evropskega sklada za regionalni razvoj.