Xanthophylls are oxygenated derivatives of carotenoids and, as natural biologically active compounds with known pharmacological properties, they have many positive effects on human health. For some esterified xanthophylls it was shown that they have superior stability and bioavailability compared to their free form. We have developed an energy-efficient and environmentally friendly synthetic platform for the preparation of a variety of xanthophyll esters. This platform can be applied to pigments in pure form (eg., lutein, zeaxanthin, β-cryptoxanthin, capsanthin, violaxanthin), but extracts of natural renewable sources containing these xanthophylls (eg., plant material and food waste) can also be used. The developed approach paves the way for a new line of dietary supplements with increased efficacy and stability, based on esterified xanthophylls.