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ANTIBACTERIAL BASED ON MONOCYCLIC FRAGMENTS COUPLED TO AMINOPIPERIDINE

Innovative right hand side fragments bind primarily to the bacterial DNA gyrase enzyme, providing excellent antibacterial potencies of the entire NBTI compounds at the enzyme and bacterial-cell level compared to existing NBTI agents. They also exhibit a broad spectrum of antibacterial activity and selectivity for a bacterial enzyme compared to the analogous human enzyme. Despite the undesirable cardiotoxicity, the difference in the strength of the effect on bacterial cells and toxicity indicates the possibility of achieving an appropriate therapeutic window.…

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COILED-COIL MEDIATED TETHERING OF CRISPR/CAS AND EXONUCLEASES FOR ENHANCED GENOME EDITING

The global gene editing market is growing with more than 15% CAGR and what propels it are multiple applications; from drug discovery processes and high-value personalized medicines to microorganisms and plant genetic engineering. Another market driver are increasingly accessible gene editing tools. CRISPR/Cas is an important one, holding about 50% of the market due to its multiplexing ability and a relatively easy design. It consists out of an endonuclease, called Cas9, and an engineered chimeric guide RNA that matches DNA…

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SMALL MOLECULE-INHIBITORS OF 6-PHOSPHOFRUCTO-1-KINASE FOR SUPPRESING

Consistent characteristic of malignant cells is the consumption of a larger amount of glucose compared to the normal cells and conversion of majority of glucose into lactic acid. Lactate that is transported out of the cells causes acidification in tumors that contributes to immune escape, besides lactate induces angiogenesis and migration of cancer cells. Manipulation of glycolysis in the cancer cells with an aim to reduce lactate.

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SUSTAINABLE FIBER-FORMING FLAME RETARDANT POLYAMIDE 6

Scientists from the National Institute of Chemistry and the Faculty of Natural Sciences and Engineering at the University of Ljubljana (NTF-UL) are developing functionalized ε-caprolactam ring with phosphorus flame retardant group, fibre-forming flame retardant polyamide 6 with covalently attached flame retardant side functionality, as well as the textile filaments. This represents a scientific and technological breakthrough in the development of advanced flame retardant polymers and melt-spun textile ibres.

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WASH-RESISTANT WATER- AND OIL-REPELLENT SELF-CLEANING COTTON TEXTILE

Scientists from the National Institute of Chemistry and the Faculty of Natural Sciences and Engineering at the University of Ljubljana are developing advanced multifunctional technical textile materials with high added value, which represents a scientific and technological breakthrough in the development of technologically innovative textile manufacturing processes.

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DESIGN OF SPLIT-SUPERANTIGEN FOR A SAFER CANCER IMMUNOTHERAPY

The global cancer immunotherapy market is growing due to an increasing incidence of cancer and new opportunities are emerging with a concept of deploying immune system to fight the disease. In 2016, the value of the market was at approximately USD 61 bn and the projected CAGR is 14% by 2021. One of the potential therapies is to use superantigens (SAg), which are proteins produced by bacteria or viruses and are one of the most potent activators of the immune…

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ENHANCING LIGNO-CELLULOSE CONVERSION INTO BIO-FUELS BY GENETICALLY MODIFIRED YEAST

Industrial plants and traffic largely depend on exploitation of fossil fuels, however due to the global heating renewable energy sources are becoming more important.  Bio-ethanol production from plant biomass is a promising option. Yeast Saccharomyces cerevisiae is appropriate microorganism for that because it is resistant to high ethanol concentrations. Unfortunately, S. cerevisiae is unable to metabolize pentose sugars that are abundantly present in plant material. Therefore, a lot of effort was invested in engineering genetically modified yeast.

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EXTERNALL REGULATION OF CAR T-CELL ACTIVITY FOR A SAFER AND EFFECTIVE CANCER

Chimeric antigen receptor T cells (CAR T) cancer therapies are advanced and high-value therapies that enhance the immune response against tumor cells. Tumor specificity is achieved by genetically modifying T-cells. As of 2019, two of such therapies were available in the US and some EU markets, both targeting the CD19 antigen. The latter is expressed in cancers such as diffuse large B-cell lymphoma. The development of new CAR T-cell therapies is going towards new antigen targets and limiting the adverse…

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Okrogla Miza: Vloga znanosti in inovacij pri prilagajanju na podnebne spremembe

Okrogla miza Vloga znanosti in inovacij pri prilagajanju na podnebne spremembe je bila organizirana v sodelovanju z gibanjem Mladi za podnebno pravičnost, ki so dogodek tudi povezovali.   Več informacij najdete na spletni strani Kemijskega inštituta ter na Facebook strani, kjer si lahko ogledate video posnetek: https://www.ki.si/novice/single-prikaz/novice/novica/omizje-vloga-znanosti-in-inovacij-pri-prilagajanju-na-podnebne-spremembe/?tx_ttnews%5BcalendarMonth%5D=6&tx_ttnews%5BcalendarYear%5D=2020&cHash=d2d25f78f14509380c20d1e1d82ca376 https://www.facebook.com/watch/live/?v=2287824978193947&ref=watch_permalink

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Naložbo sofinancirata Republika Slovenija in Evropska unija iz Evropskega sklada za regionalni razvoj.