KI

SUBSTITUTED BITHIAZOLES FOR THE TREATMENT OF CANCER

The present invention relates to novel chemotherapeutics, substituted bithazoles, with a potentially safer therapeutic profile. Discovered compounds inhibit human DNA topoisomerase II via an alternative mechanism, thus avoiding the DNA damage. This lowers the chances of cardiotoxicity and induction of secondary malignancies, side effects associated with clinically used topo II drugs. Compounds can be used as a standalone chemotherapy or in combination with other anticancer drugs.

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ONE-STEP SYNTHESIS OF GLYCIDOL FROM GLYCEROL IN GAS-PHASE FIXED-BED CONTINOUS FLOW REACTOR OVER ALKALI METAL PROMOTED ALUMINOSILICATE ZEOLITE CATALYST

The present invention relates to the use of alkali metal promoted aluminosilicate zeolite catalyst for the direct gas-phase conversion of glycerol to glycidol, as well as to a process for the production of glycidol from glycerol in a fixed-bed continuous flow reactor in the presence of such a heterogeneous catalyst. The method comprises conversion of glycerol to glycidol in the range of temperature 250-450 °C, glycerol concentration 1-60 wt%, total gas hourly space velocity 100-2500 h-1, weight of catalyst 0.5-5.0…

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SUSTAINABLE PRODUCTION OF ALLYL ALCOHOL: GAS-PHASE CONVERSION OF GLYCEROL OVER METALS PROMOTED ALUMINOSILICATE ZEOLITE CATALYSTS IN A FIXED-BED CONTINUOUS FLOW REACTOR

The present invention relates to the use of a tri-metallic promoted aluminosilicate zeolite catalyst for the direct gas-phase conversion of glycerol to allyl alcohol, as well as to a process for the production of allyl alcohol from glycerol in a fixed-bed continuous flow reactor in the presence of such heterogeneous catalysts. The method comprises conversion of glycerol to allyl alcohol in the range of temperature 250-450 °C, glycerol concentration 1-60 wt%, total gas hourly space velocity 100-2000 h-1, the weight…

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SUSTAINABLE PROCESS FOR PRODUCING MUCONIC, HEXENEDIOIC AND ADIPIC ACID (AND THEIR ESTERS) FROM ALDARIC ACIDS BY HETEROGENEOUS CATALYSIS

The Institute’s invention is a process based on selective dehydroxylation of aldaric acids derived from C6 oxidized sugars. The selective dehydroxylation is carried out in the presence of a heterogeneous carbon supported rhenium catalyst (Re/C) and a short chain primary or secondary alcohol (MeOH, EtOH, 2-PrOH,…). Under an inert (N2) atmosphere, unsaturated dimethyl ester of a C6 dicarboxylic acid is formed. If H2 is present in the gas phase, it is dissolved in MeOH and adsorbed on the catalyst surface,…

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A PROCESS FOR ENGINEERING MORE EFFICIENT AND CHEAPER CATALYSTS FOR HYDROGEN FUEL CELLS

Hydrogen fuel cells will have an important role in reducing carbon footprint as they offer environmentally friendly alternative to fossil-based fuels by converting hydrogen as a fuel and oxygen from the air in clean electricity with only by-product being water. In 2016, the fuel cells’ global market value was estimated at 3.2bn USD with 20% CAGR that will lead to up-to 25bn USD by 2025. This is a versatile energy source with many potential applications in the transport sector as…

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CELL-BASED DEVICE FOR LOCAL TREATMENT WITH THERAPEUTIC PROTEINS

The Institute’s invention is a device that is comprised of a Teflon tube, permanently sealed on both ends, which contains stable cell lines. Different types of injuries demand different types of regenerative process and the device usually carries multiple types of cells, secreting multiple types of growth factors. This approach enables more control over the regeneration process and consequently better outcomes.

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SILYLATED CELLULOSE BASED INTERFACIAL PROTECTIVE LAYER ON A LITHIUM SURFACE

Lithium metal batteries are among the most promising candidates for next-generation high-density energy storage devices due to unrivalled high specific capacity and the lowest reduction potential of lithium metal anode. Estimations are that the global market will grow with a CAGR of 17% and reach the value of USD 100bn by 2025. This growth also depends on solving some of the current challenges. The usage of the lithium metal anode is obstructed by at least three issues; dendritic deposition of…

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SELF-ASSEMBLED PROTEIN NANOSTRUCTURES

This invention applies to a new technology with the help of which it is possible to plan polypeptide chains which, by self-assembly, form protein nanostructures. Polypeptides are assembled modularly from linked peptide segments that in pairs form coils and thus the side of a polyhedron. The invention makes it possible to design new protein structures not found in nature, and the input of selected functions into positions with nanometer resolution, which makes it possible to prepare technologically interesting advanced nanomaterials.…

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Naložbo sofinancirata Republika Slovenija in Evropska unija iz Evropskega sklada za regionalni razvoj.