MiricaKarlovits

Consistent characteristic of malignant cells is the consumption of a larger amount of glucose compared to the normal cells and conversion of majority of glucose into lactic acid. Lactate that is transported out of the cells causes acidification in tumors that contributes to immune escape, besides lactate induces angiogenesis and migration of cancer cells. Manipulation of glycolysis in the cancer cells with an aim to reduce lactate.

Scientists from the National Institute of Chemistry and the Faculty of Natural Sciences and Engineering at the University of Ljubljana (NTF-UL) are developing functionalized ε-caprolactam ring with phosphorus flame retardant group, fibre-forming flame retardant polyamide 6 with covalently attached flame retardant side functionality, as well as the textile filaments. This represents a scientific and technological breakthrough in the development of advanced flame retardant polymers and melt-spun textile ibres.

The invention is a smart label that irreversibly indicates cumulative time of heating above the pre-defined temperature. The invented time-temperature indicator (TTI) is thin, flexible and self-adhesive.

Scientists from the National Institute of Chemistry and the Faculty of Natural Sciences and Engineering at the University of Ljubljana are developing advanced multifunctional technical textile materials with high added value, which represents a scientific and technological breakthrough in the development of technologically innovative textile manufacturing processes.

The global cancer immunotherapy market is growing due to an increasing incidence of cancer and new opportunities are emerging with a concept of deploying immune system to fight the disease. In 2016, the value of the market was at approximately USD 61 bn and the projected CAGR is 14% by 2021. One of the potential therapies is to use superantigens (SAg), which are proteins produced by bacteria or viruses and are one of the most potent activators of the immune…

Industrial plants and traffic largely depend on exploitation of fossil fuels, however due to the global heating renewable energy sources are becoming more important.  Bio-ethanol production from plant biomass is a promising option. Yeast Saccharomyces cerevisiae is appropriate microorganism for that because it is resistant to high ethanol concentrations. Unfortunately, S. cerevisiae is unable to metabolize pentose sugars that are abundantly present in plant material. Therefore, a lot of effort was invested in engineering genetically modified yeast.

Chimeric antigen receptor T cells (CAR T) cancer therapies are advanced and high-value therapies that enhance the immune response against tumor cells. Tumor specificity is achieved by genetically modifying T-cells. As of 2019, two of such therapies were available in the US and some EU markets, both targeting the CD19 antigen. The latter is expressed in cancers such as diffuse large B-cell lymphoma. The development of new CAR T-cell therapies is going towards new antigen targets and limiting the adverse…

In the cell-based device presented, the therapeutic effects of stem cells on the injured tissue are mimicked by encapsulated cells applied to the affected tissue. At the site of injury, these engineered cells are programmed to secrete therapeutic proteins.

Cancer is one of the most widespread diseases and the second leading cause of death, with WHO reporting almost 10 million deaths annually. The human DNA topoisomerase IIα is a well-known and validated anticancer target for chemotherapy, catalyzing topological changes of the DNA molecule.