KI

Chimeric antigen receptor T cells (CAR T) cancer therapies are advanced and high-value therapies that enhance the immune response against tumor cells. Tumor specificity is achieved by genetically modifying T-cells. As of 2019, two of such therapies were available in the US and some EU markets, both targeting the CD19 antigen. The latter is expressed in cancers such as diffuse large B-cell lymphoma. The development of new CAR T-cell therapies is going towards new antigen targets and limiting the adverse…

In the cell-based device presented, the therapeutic effects of stem cells on the injured tissue are mimicked by encapsulated cells applied to the affected tissue. At the site of injury, these engineered cells are programmed to secrete therapeutic proteins.

Cancer is one of the most widespread diseases and the second leading cause of death, with WHO reporting almost 10 million deaths annually. The human DNA topoisomerase IIα is a well-known and validated anticancer target for chemotherapy, catalyzing topological changes of the DNA molecule.

The present invention relates to the use of alkali metal promoted aluminosilicate zeolite catalyst for the direct gas-phase conversion of glycerol to glycidol, as well as to a process for the production of glycidol from glycerol in a fixed-bed continuous flow reactor in the presence of such a heterogeneous catalyst. The method comprises conversion of glycerol to glycidol in the range of temperature 250-450 °C, glycerol concentration 1-60 wt%, total gas hourly space velocity 100-2500 h-1, weight of catalyst 0.5-5.0…

The present invention relates to the use of a tri-metallic promoted aluminosilicate zeolite catalyst for the direct gas-phase conversion of glycerol to allyl alcohol, as well as to a process for the production of allyl alcohol from glycerol in a fixed-bed continuous flow reactor in the presence of such heterogeneous catalysts. The method comprises conversion of glycerol to allyl alcohol in the range of temperature 250-450 °C, glycerol concentration 1-60 wt%, total gas hourly space velocity 100-2000 h-1, the weight…

The Institute’s invention is a process based on selective dehydroxylation of aldaric acids derived from C6 oxidized sugars. The selective dehydroxylation is carried out in the presence of a heterogeneous carbon supported rhenium catalyst (Re/C) and a short chain primary or secondary alcohol (MeOH, EtOH, 2-PrOH,…). Under an inert (N2) atmosphere, unsaturated dimethyl ester of a C6 dicarboxylic acid is formed. If H2 is present in the gas phase, it is dissolved in MeOH and adsorbed on the catalyst surface,…

Our researchers have discovered an entirely new approach to agricultural crops protection against microbial pathogens. Pathogenic microbes affecting fruit and vegetables such as potatoes, soybeans, tomatoes, tobacco and vines, secrete a number of harmful molecules that allow the microbes to infect and spread along the plant.

The Institute’s invention is a device that is comprised of a Teflon tube, permanently sealed on both ends, which contains stable cell lines. Different types of injuries demand different types of regenerative process and the device usually carries multiple types of cells, secreting multiple types of growth factors. This approach enables more control over the regeneration process and consequently better outcomes.

Lithium metal batteries are among the most promising candidates for next-generation high-density energy storage devices due to unrivalled high specific capacity and the lowest reduction potential of lithium metal anode. Estimations are that the global market will grow with a CAGR of 17% and reach the value of USD 100bn by 2025. This growth also depends on solving some of the current challenges. The usage of the lithium metal anode is obstructed by at least three issues; dendritic deposition of…